Modelización hidrológica del río Odiel : aplicación al estudio de la contaminación por drenaje ácido de minas

La cuenca del río Odiel está intensamente contaminada por el drenaje ácido de minas procedente de las numerosas instalaciones mineras diseminadas por toda la cuenca. Para evaluar la carga contaminante transportada por el río Odiel es necesario disponer de series de caudal continuas espacial y temporalmente. Por eso se realizó la modelización hidrológica del río Odiel mediante el programa Soil and Water Assessment Tool (SWAT). Las mayores diferencias entre el caudal simulado y el observado se produjeron durante el estiaje, debido a que la estación de aforo no dispone de un vertedero canalizado para aguas bajas. Tras la calibración se obtuvo un valor muy bueno del coeficiente de eficiencia de Nash y Sutcliffe. Así, se obtuvo que el río Odiel, justo antes de su desembocadura en la ría de Huelva transportó cantidades enormes de elementos tóxicos tales como Al (18935 ton/año), Zn (5695 ton/año) y sulfatos (320775 ton/año).The Odiel river basin is highly contaminated by acid mine drainage coming from numerous mines scattered across its basin. Continuous temporal and spatial data series are needed in order to evaluate the pollutant load carried by the Odiel river. A hydrological modeling of the Odiel watershed has been developed using the Soil and Water Assessment Tool (SWAT) software. The largest differences between observed and simulated flow occurred during dry season as the gauging station is not prepared for low water measuring. The results showed a very good value of the Nash and Sutcliffe efficiency coefficient. The results show that de Odiel river, before it flows into the estuary of Huelva, transported large amounts of toxic elements such as Al (18935 ton/year), Zn (5695 ton/year) y sulfates (320775 ton/year)

La educación socioemocional a través de la literatura infantil inglesa

El presente Trabajo de Fin de Grado tiene como objetivo demostrar la importancia de la educación socioemocional en las etapas de Educación Primaria para lograr un buen desarrollo tanto personal como social en el alumnado y fomentar la adquisición de conocimientos a través de la literatura infantil como un potente recurso educativo, concretamente por medio de los cuentos. Para ello se ha elaborado una propuesta de intervención para 4º de Educación Primaria que tiene como base dos cuentos en inglés What do you do with an idea? y What do you do with a problem? para así comprender los pensamientos personales y resolver los conflictos comunes de estas edades. Así, los estudiantes entenderán sus sentimientos y emociones basándose en el respeto y la empatía.This present Final Project aims to show the importance of the socioemotional education in the Primary Education to achieve a good personal and social development in the students and to foster the acquisition of knowledge through children´s literature as it is a powerful educational resource and specifically by means of tales. For this purpose, an educational intervention proposal has been elaborated for the 4th grade of Primary Education and it is based on two English tales What do you do with an idea? and What do you do with a problem? These two tales have the aim to understand the personal thoughts and to solve the common conflicts at the students’ ages. Because of that, the students will understand their feelings and emotions based on respect and empathy.Grado en Educación Primari

Métricas de Registro de Imágenes y Predicción de Dolor de Rodilla por Osteoartritis Crónica: Datos de la Osteoarthritis Initiative

Osteoarthritis (OA) is the most common type of arthritis, is a growing disease in the industrialized world. OA is an incapacitate disease that affects more than 1 in 10 adults over 60 years old. X-ray medical imaging is a primary diagnose technique used on staging OA that the expert reads and quantify the stage of the disease. Some Computer-Aided Diagnosis (CADx) efforts to automate the OA detection have been made to aid the radiologist in the detection and control, nevertheless, the pain inherits to the disease progression is left behind. In this research, it’s proposed a CADx system that quantify the bilateral similarity of the patient’s knees to correlate the degree of asymmetry with the pain development. Firstly, the knee images were aligned using a B-spline image registration algorithm, then, a set of similarity measures were quantified, lastly, using this measures it’s proposed a multivariate model to predict the pain development up to 48 months. The methodology was validated on a cohort of 131 patients from the Osteoarthritis Initiative (OAI) database. Results suggest that mutual information can be associated with K&L OAI scores, and Multivariate models predicted knee chronic pain with: AUC 0.756, 0.704, 0.713 at baseline, one year, and two years’ follow-up.Osteoarthritis (OA) is the most common type of arthritis, is a growing disease in the industrialized world. OA is an incapacitate disease that affects more than 1 in 10 adults over 60 years old. X-ray medical imaging is a primary diagnose technique used on staging OA that the expert reads and quantify the stage of the disease. Some Computer-Aided Diagnosis (CADx) efforts to automate the OA detection have been made to aid the radiologist in the detection and control, nevertheless, the pain inherits to the disease progression is left behind. In this research, it’s proposed a CADx system that quantify the bilateral similarity of the patient’s knees to correlate the degree of asymmetry with the pain development. Firstly, the knee images were aligned using a B-spline image registration algorithm, then, a set of similarity measures were quantified, lastly, using this measures it’s proposed a multivariate model to predict the pain development up to 48 months. The methodology was validated on a cohort of 131 patients from the Osteoarthritis Initiative (OAI) database. Results suggest that mutual information can be associated with K&L OAI scores, and Multivariate models predicted knee chronic pain with: AUC 0.756, 0.704, 0.713 at baseline, one year, and two years’ follow-up

A generalized model for indoor location estimation using environmental sound from human activity recognition

The indoor location of individuals is a key contextual variable for commercial and assisted location-based services and applications. Commercial centers and medical buildings (eg, hospitals) require location information of their users/patients to offer the services that are needed at the correct moment. Several approaches have been proposed to tackle this problem. In this paper, we present the development of an indoor location system which relies on the human activity recognition approach, using sound as an information source to infer the indoor location based on the contextual information of the activity that is realized at the moment. In this work, we analyze the sound information to estimate the location using the contextual information of the activity. A feature extraction approach to the sound signal is performed to feed a random forest algorithm in order to generate a model to estimate the location of the user. We evaluate the quality of the resulting model in terms of sensitivity and specificity for each location, and we also perform out-of-bag error estimation. Our experiments were carried out in five representative residential homes. Each home had four individual indoor rooms. Eleven activities (brewing coffee, cooking, eggs, taking a shower, etc.) were performed to provide the contextual information. Experimental results show that developing an indoor location system (ILS) that uses contextual information from human activities (identified with data provided from the environmental sound) can achieve an estimation that is 95% correct

La integración Vertical del producto Clamshell, reduce costos de producto y transportación en el Mercado Comercial Automotriz

The next study was implemented in a company dedicated to the automotive manufacture of windshield wiper products that is distributed in the commercial and original equipment market, the objective is the implementation of a vertical integration to the packaging product. In this project, the "clamshell product" is developed in packaging product of 20” for Pro-Flex brand. The principal vision is to reduce product costs and reduce transportation costs between external supplier and manufacturing plant. What stands out, the elimination of suppliers develops greater sustainability in the supply of raw materials, which has economic benefits for the company, as well as its transportation and logistics, implementing continuous improvement in the supply of packaging into the production lines for principal customers. Similarly, reduce the time lost due to material shortages within the palletizing system, due to external supplier problems, and the number of production line stoppages in production and sales schedules.El siguiente estudio se realizó en una empresa dedicada a la manufactura automotriz de productos limpiaparabrisas que se distribuye en el mercado comercial y de equipo original, el objetivo es la implementación de una integración vertical al producto de empaque. En el presente proyecto, se desarrolla sobre el “producto clamshell” en los empaques de 20” para la marca Pro-Flex, la principal visión es tener la reducción de costos de producto y la reducción de costos transportación entre proveedor externo y planta manufacturera. Dentro de lo destacado, la eliminación de proveedores desarrolla mayor sustentabilidad en el suministro de materia prima, lo cual tiene beneficios económicos para la empresa, así como la transportación y logística de este, implementando la mejora continua en el suministro de empaques dentro de las líneas de producción a cliente principal. De igual forma, reducir el tiempo perdido por desabasto de material dentro del sistema de paletizado, debido a las problemáticas de proveedor externo, y la cantidad de paros de línea de producción en las programaciones de producción y ventas

Significant Clinical Activity of Olaparib in a Somatic BRCA1-Mutated Triple-Negative Breast Cancer With Brain Metastasis

Breast cancer is a biologically and clinically heterogeneous disease, and patients with similar clinical stage have markedly different outcomes. Triple-negative breast cancer (TNBC) is defined by the lack of expression of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2 (HER2).1,2 This subtype represents 15% to 20% of all breast cancers and is associated with the worst outcome of all subtypes, with greater tendency to distant recurrence in general and visceral metastasis in particular, including brain metastasis.3,4 To date, chemotherapy remains the standard of care for TNB

Persistence of COVID-19 Symptoms after Recovery in Mexican Population

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease (COVID-19), a highly contagious infectious disease that has caused many deaths worldwide. Despite global efforts, it continues to cause great losses, and leaving multiple unknowns that we must resolve in order to face the pandemic more effectively. One of the questions that has arisen recently is what happens, after recovering from COVID-19. For this reason, the objective of this study is to identify the risk of presenting persistent symptoms in recovered from COVID-19. This case-control study was conducted in one state of Mexico. Initially the data were obtained from the participants, through a questionnaire about symptoms that they had at the moment of the interview. Initially were captured the collected data, to make a dataset. After the pre-processed using the R project tool to eliminate outliers or missing data. Obtained finally a total of 219 participants, 141 recovered and 78 controls. It was used confidence level of 90% and a margin of error of 7%. From results it was obtained that all symptoms have an associated risk in those recovered. The relative risk of the selected symptoms in the recovered patients goes from 3 to 22 times, being infinite for the case of dyspnea, due to the fact that there is no control that presents this symptom at the moment of the interview, followed by the nausea and the anosmia with a RR of 8.5. Therefore, public health strategies must be rethought, to treat or rehabilitate, avoiding chronic problems in patients recovered from COVID-19

Oral metronomic vinorelbine combined with endocrine therapy in hormone receptor-positive HER2-negative breast cancer: SOLTI-1501 VENTANA window of opportunity trial

Background: The biological effect of oral metronomic vinorelbine (mVNB) alone or in combination with endocrine therapy in patients with hormone receptor-positive (HR+)/HER2-negative breast cancer has been scarcely addressed. Methods: Postmenopausal women with untreated stage I-III HR+/HER2-negative breast cancer were randomized (1:1:1) to receive 3 weeks of letrozole (LTZ) 2.5 mg/day, oral mVNB 50 mg 3 days/week, or the combination. The primary objective was to evaluate, within PAM50 Luminal A/B disease, if the anti-proliferative effect of LTZ+mVNB was superior to monotherapy. An anti-proliferative effect was defined as the mean relative decrease of the PAM50 11-gene proliferation score in combination arm vs. both monotherapy arms. Secondary objectives included the evaluation of a comprehensive panel of breast cancer-related genes and safety. An unplanned analysis of stromal tumor-infiltrating lymphocytes (sTILs) was also performed. PAM50 analyses were performed using the nCounter®-based Breast Cancer 360 gene panel, which includes 752 genes and 32 signatures. Results: Sixty-one patients were randomized, and 54 paired samples (89%) were analyzed. The main patient characteristics were mean age of 67, mean tumor size of 1.7 cm, mean Ki67 of 14.3%, stage I (55.7%), and grades 1-2 (90%). Most baseline samples were PAM50 Luminal A (74.1%) or B (22.2%). The anti-proliferative effect of 3 weeks of LTZ+mVNB (- 73.2%) was superior to both monotherapy arms combined (- 49.9%; p = 0.001) and mVNB (- 19.1%; p < 0.001). The anti-proliferative effect of LTZ+mVNB (- 73.2%) was numerically higher compared to LTZ (- 65.7%) but did not reach statistical significance (p = 0.328). LTZ+mVNB induced high expression of immune-related genes and gene signatures, including CD8 T cell signature and PDL1 gene and low expression of ER-regulated genes (e.g., progesterone receptor) and cell cycle-related and DNA repair genes. In tumors with ≤ 10% sTILs at baseline, a statistically significant increase in sTILs was observed following LTZ (paired analysis p = 0.049) and LTZ+mVNB (p = 0.012). Grade 3 adverse events occurred in 3.4% of the cases. Conclusions: Short-term mVNB is well-tolerated and presents anti-proliferative activity alone and in combination with LTZ. The high expression of immune-related biological processes and sTILs observed with the combination opens the possibility of studying this combination with immunotherapy. Further investigation comparing these biological results with other metronomic schedules or drug combinations is warranted

Overexpression of proCOL11A1 as a stromal marker of breast cancer

Background: Our previous studies demonstrated the expression of procollagen11A1 in fibroblasts of pancreatic cancer desmoplasia and the lack of expression in fibroblasts of pancreatitis by means of the polyclonal antibody (anti-proCOL11A1 pAb) we generated. In a similar way, we decided to compare the expression of procollagen11A1 in fibroblasts of infiltrating ductal carcinoma of the breast and fibroblasts of benign sclerosing lesions of the breast, in order to validate the anti-proCOL11A1 pAb in this setting and to study how proCOL11A1 expression relates to other prognostic and predictive factors, as well as to survival. Methods: 45 core biopsies of sclerosing adenosis and 50 core biopsies of infiltrating ductal carcinoma of the breast were stained with anti-proCOL11A1 pAb, a polyclonal antibody highly specific to the less homologous fraction of proCOL11A1 (in comparison with proCOL5A1 and proCOL11A2). In addition, the expression of the proCOL11A1 gene was measured by RT-qPCR. On the other hand, the expression of proCOL11A1 was compared to the expression of estrogenic receptors, progestagen receptors, the state of the epidermal growth factor receptor 2 (HER2), the histologic grade and the stage of the disease. We also compared the immunohistochemical expression of proCol11A1 to the disease-free interval, and to overall survival. Results: The immunohistochemical analysis showed that proCOL11A1 was expressed in 100% of infiltrating ductal carcinomas, but only focally expressed in 2.2% (1 case) of sclerosing adenosis, in agreement with RT-qPCR results. ProCOL11A1 expression did not prove to have a prognostic value in relation to the disease-free interval or to overall survival in infiltrating ductal carcinoma. Conclusion: The anti-proCOL11A1 pAb is a stromal marker for breast cancer and the expression of proCOL11A1 does not seem to have a prognostic value in infiltrating ductal carcinoma of the breast

Investigación joven con perspectiva de género VI

Actas del VI Congreso Internacional de Jóvenes Investigadorxs con perspectiva de género (Getafe, 16 - 18 de junio de 2021) organizado por el Instituto Universitario de Estudios de Género de la Universidad Carlos III de Madrid.El concepto de la vejes en la literatura griega arcaica / María Secades Fonseca se inscribe en el marco del Proyectos de I+D+i del Ministerio de Ciencia e Innovación, titulado Vulnerabilidad intrafamiliar y política en el mundo antiguo y dirigido por Susana Reboreda Morillo y Rosa María Cid López (Ref. PID2020-116349GB-I00).Generando una interpretación del Derecho en clave de igualdad de género / Alicia Cárdenas Cordón y Gloria Serrano Valverde es un trabajo elaborado y presentado en el marco del Proyecto de Investigación RTI2018-10669-B-100 ‘‘GEN-DER: Generando una interpretación del Derecho en clave de igualdad de género’’, enmarcado en el Programa Estatal de I+D+i Orientada a los Retos de la Sociedad- Ministerio de Ciencia e Innovación (2019-2021)